Juniper Publishers Journal of Reproductive Medicine

JUNIPER PUBLISHERS-GLOBAL JOURNAL OF REPRODUCTIVE MEDICINE Pregnancy in a Obese Married Lady with Hyperprolactinemia, Severe Hypertension Mildly Raised ACTH with Symptomatic Treatment Like Topiramate, Caberlin, Labetolololand Cycle Correction-Live Healthy Baby Authored by  Kulvinder Kaur A 29 year old patient married for 5 years presented with irregular cycles, obesity and primary infertility of 5 years. On examination she was hypertensive with BP 190/110mm HG, Ht- 180cm, Wt-120kg BMI, 37.3Kg/m 2  SFSH- 6.2iu/l, LH- 9.2IU/L, S prolactin- 191ng/ml (5-29ng/ml), Thyroid function test was normal, s.cortisol-5(wnl), SDHES-WNL, GTT-within normal limits, postprandial insulin 56u-wnl, s testosterone was 0.6ng/ ml (0.2- 0.8ng/ml). ACTH was increased to 56pu/ml. Hence low dose and high dose dexamethasone suppression was done which was within normal limits. To Read More..... Full Text in  Global Journal of Reproductive Medicine in  Juniper Publishers

JUNIPER PUBLISHERS-GLOBAL JOURNAL OF REPRODUCTIVE MEDICINE How Much Inconvenience and Discomfort does Modern IVF Treatment Cause? Authored by Gab Kovacs IVF is widely practiced, however, data on the degree of discomfort and inconvenience experienced by women undergoing treatment is nonexistent. We surveyed women being treated at Monash IVF, undergoing oocyte collection in stimulated cycles at Epworth Hawthorn Day Surgery. One hundred and eighteen women were recruited to the study during a five week period from August to September 2014 and underwent a five minute telephone interview asking ten questions. Women were asked to rate the inconvenience and pain associated with the blood tests, injections and oocyte collection procedure using a numeric rating scale of zero to ten. Data on analgesic usage and the time taken to return to work and normal activity was also recorded. The median number of oocytes was nine. The mean pain score immediately post operation was 4.6, a...

JUNIPER PUBLISHERS-GLOBAL JOURNAL OF REPRODUCTIVE MEDICINE Cultivating a Support Network: Granulosa Cells and the Needed Knowledge on their Role in Oocyte Maturation Authored by  Esther Lopez-Bayghen Maintaining and restoring full developmental competence of oocytes after a process of cryopreservation to preserve fertility is a growing concern in the field of assisted reproductive technologies (ART). Unfortunately, attempts so far have been characterized by low quality and a poor yield of live births. A promising avenue of research is to replicate the microenvironment of the follicles to achieve careful cryopreservation and successful  in vitro  maturation. A key step for this is to understands the interactions between somatic granulosa cells and the oocyte that are required for maturation and developmental competence. In the present work we present a succinct review of these molecular interactions, including endocrine and paracrine signaling, gene regula...

JUNIPER PUBLISHERS-GLOBAL JOURNAL OF REPRODUCTIVE MEDICINE Cultivating a Support Network: Granulosa Cells and the Needed Knowledge on their Role in Oocyte Maturation Authored by Esther López-Bayghen Maintaining and restoring full developmental competence of oocytes after a process of cryopreservation to preserve fertility is a growing concern in the field of assisted reproductive technologies (ART). Unfortunately, attempts so far have been characterized by low quality and a poor yield of live births. A promising avenue of research is to replicate the microenvironment of the follicles to achieve careful cryopreservation and successful  in vitro  maturation. A key step for this is to understands the interactions between somatic granulosa cells and the oocyte that are required for maturation and developmental competence. In the present work we present a succinct review of these molecular interactions, including endocrine and paracrine signaling, gene regulation a...

JUNIPER PUBLISHERS-GLOBAL JOURNAL OF REPRODUCTIVE MEDICINE Female Urethral Ectropion Authored by Jimmy Kayastha* A 67-year-old woman suffering from lupus with corticosteroids for 3 years, has repeatedly consulted for urinary signs: essentially recurrent cystitis. The time between onset of symptoms and diagnosis was 38 months. Gynecological examination (Figure 1) revealed adistal diverticulum palpable along the urethral path. The cytobacteriological examination of the urine had isolated an Escherichia coli resistant to the usual antibiotics.  To read more.... Full Text in Global Journal of Reproductive Medicine in Juniper Publishers

JUNIPER PUBLISHERS-GLOBAL JOURNAL OF REPRODUCTIVE MEDICINE Neem ( Azadirachta Indica  L.) and Oocyte Quality Authored by Arindam Bhattacharjee Neem (Azadirachta indica L.) leaf has been used as a birth control in traditional as well as ayurvedic systems of medicine for a long time.The molecular mechanism by which neem bioactive ingredients regulate female fertility remains poorly understood. Studies carried out on experimental mammals suggest that neem leaf extract induces generation of reactive oxygen species (ROS) in ovarian follicles. The increased ROS level induces granulosa cell apoptosis through mitochondria-mediated pathway. Premature death of encircling granulosa cells directly affect the achievement of meiotic competence and thereby oocyte quality after ovulation. In addition, the increased levels of ROS enter in the follicular oocytes and deteriorate its quality by inducing mitochondria-mediated apoptosis. The granulosa cells as well as oocyte apoptosis wit...

JUNIPER PUBLISHERS-GLOBAL JOURNAL OF REPRODUCTIVE MEDICINE Human Shape: A New Proposed Criterion for Fetal Personhood Authored by Seyed Mohammad Azin This perspective aims at introduction of a new criterion for fetal personhood based on Shii’a thought. Although there is a known idea in Islamic Shii'a jurisprudence which identifies end of fourth month of pregnancy as the moment of acquiring personhood, this paper suggests end of third month as the point at which the fetus has to be considered human person. To read more.... Full Text in Global Journal of Reproductive Medicine in Juniper Publishers

JUNIPER PUBLISHERS-GLOBAL JOURNAL OF REPRODUCTIVE MEDICINE GHR106 Monoclonal Antibody is Bioequivalent to GnRH Peptide Analogs Authored by Gregory Lee* GnRH (gonadotropin releasing hormone) is a decapeptide hormone and was discovered initially to react with GnRH receptor in the anterior pituitary. This hormone serves to stimulate the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) for the differentiation and maturations of reproductive functions. Due to the relative short half-life of GnRH (in min) in circulations, numerous peptide analogs were made available to increase the half-life of these GnRH analogs to hours. Due to structural modifications, they were classified into either agonists or antagonists, depending on their respective biological actions . To Read More...... PDF in  Global Journal of Reproductive Medicine in Juniper Publishers