Neem (Azadirachta Indica L.) and Oocyte Quality-Juniper Publishers-Global Journal Of Reproductive Medicine

JUNIPER PUBLISHERS-GLOBAL JOURNAL OF REPRODUCTIVE MEDICINE

Neem (Azadirachta Indica L.) and Oocyte Quality

Authored by Arindam Bhattacharjee

Neem (Azadirachta indica L.) leaf has been used as a birth control in traditional as well as ayurvedic systems of medicine for a long time.The molecular mechanism by which neem bioactive ingredients regulate female fertility remains poorly understood. Studies carried out on experimental mammals suggest that neem leaf extract induces generation of reactive oxygen species (ROS) in ovarian follicles. The increased ROS level induces granulosa cell apoptosis through mitochondria-mediated pathway. Premature death of encircling granulosa cells directly affect the achievement of meiotic competence and thereby oocyte quality after ovulation. In addition, the increased levels of ROS enter in the follicular oocytes and deteriorate its quality by inducing mitochondria-mediated apoptosis. The granulosa cells as well as oocyte apoptosis within the follicular microenvironment deteriorate oocyte quality. Poor quality directly affects fertilization, implantation and pregnancy rates and increases abortion rate. Thus, based on existing animal as well as human studies, we are in opinion that bioactive ingredients of neem particularly neem leaf extract could be used as reversible herbal female contraceptive during fertility management in human.


Comments

Post a Comment

Popular posts from this blog

Research Article Intrauterine Insemination with Fresh Versus Cryopreserved Spermatazoa in Unexplained Infertility

Image
Global Journal of Reproductive Medicine    Juniper Publishers Authored by: Sheena Rippentrop* Introduction Infertility affects approximately 14% of couples in the general population and is defined as failure to conceive after 12 months of regular unprotected intercourse. Unexplained infertility accounts for up to 15-30% of the diagnoses in couples [1,2]. The diagnosis of unexplained infertility is one of exclusion and can only be made after investigating the common causes of infertility using standard testing including evaluation for male and female infertility [1]. This evaluation typically involves assessment of ovulation, ovarian reserve, fallopian tube patency, uterine and cervical factors, along with semen analysis. In couples with infertility, previous studies have shown that ovulation induction with intrauterine insemination (IUI) provides a less invasive and more cost-effective treatment option when compared to in-vitro fertilization in couples with unexplained in
Read more

Wolfram Syndrome with Primary Gonadal Insufficiency_Juniper publishers

Image
Global Journal of Reproductive Medicine    Juniper Publishers Authored by: Muhammed Kizilgul* Abstract A 24-year old male patient admitted to our clinic with the complaints of mouth dryness, polyuria, and polydipsia. He was diagnosed with tip 1 Diabetes Mellitus (DM) at the age of seven and intensive insulin therapy was instituted subsequently. Despite the stable blood glucose levels, the daily liquid intake of the patient was 10 liters, and the urine output was 9.5 liters. The patient also had complaints of loss of libido, impotence, erectile and ejaculatory dysfunction in the last 6 months. The insulin therapy was given as insulin aspart 4-unit t.i.d and insulin detemir 12 unit per day. In the physical examination, bilateral gynecomastia was observed. In the hormonal panel; FSH: 45 U/L (N:1.5-12.7), LH:28.4 U/L (N:1.7- 8.6), total testosterone: 3.83ng/ml (N:3-10ng/ml), free testosterone: 2.15pg/ml (N:12,00-30,00pg/ml). Bone mineral densitometry revealed low bone mass for
Read more

Sperm-Oviduct Interaction Factors that Compromise Fertility of Frozen Stallion Semen

Global Journal of Reproductive Medicine   Juniper Publishers Abstract The cryopreservation procedure changes the integrity and functionality of sperm, affecting their longevity and the ability to fertilize the oocyte. Moreover, some of those changes could be alter the physiologic interactions between the sperm and the oviductal epithelial cells prior to fertilization, placing further limitations and challenges on frozen-thawed stallion sperm. For fertilization to occur, a sperm subpopulation should be survive in uterine environment and be transported to oviduct, the tubular epithelium that regulate the sperm capacitation process in tuning with the ovulation and later oocyte fecundation. Factors affecting sperm-oviduct interactions in equine and findings in other mammals suggest that this interaction is highly conserved. However, there are differences between species and this interaction may assist to explain the idiopathic infertility associated with the use of
Read more