Effect of Prolonged GnRH Agonist Therapy Prior to Frozen Embryo Transfer on IVF-ET Outcome in Patients with and without Endometrioma Surgery
GLOBAL JOURNAL OF REPRODUCTIVE MEDICINE-JUNIPER PUBLISHERS Abstract Objective : It remains to be clarified whether prolonged Gonadotrophin-Releasing Hormone agonist (GnRHa) administration before frozen embryo transfer to patients with and without endometrioma resection improves reproductive outcome. This study was designed to investigate freeze-all cycles with subsequent prolonged GnRHa administration in patients with and without endometrioma surgery. Method : A total of 164 patients with complaints of infertility and diagnosed with endometrioma were included in this case controlled study. Endometrioma resection was performed in 65 out of 164 women and then Controlled Ovarian Stimulation (COS) was performed (Group 1). Fresh embryos were transferred to 40 of 65 patients who underwent endometrioma surgery. Embryos were vitrified in 25 patients and administered leuprolide acetate 3.75 mg for 3 months. The remaining 99 patients were referred directly to the COS without any surgery for en