Global Journal of Reproductive Medicine Juniper Publishers Authored by: Neha Garg* Introduction Infertility has been a growing global public health issue. It affects one in every six couples, which is 15% couples in reproductive age group. Female factor infertility accounts for 40% [1]. Around 15% of all infertile couples and in 40% of infertile women anovulation is the cause [2]. Clomiphene citrate has been traditionally used as the first line drug in anovulatory infertility. But as a singular drug it may not be effective in all cases. Thus, the need for an adjuvant which is a drug or a substance that enhances the activity of another or a substance added to a medicinal preparation to assist the action of the principal ingredient. Aspirin, L-arginine, oestrogens, glucocorticoids, spironolactone, cyproterone acetate, dehydroepiandrosterone, metformin, etc. are some of the adjuvants being used. Considering the high prevalence of insulin resistance and hy...