Juniper Publishers: Simultaneous Estimation of Aliskiren and Amlodipin...

Juniper Publishers: Simultaneous Estimation of Aliskiren and Amlodipin...: Journal of Organic & Medicinal Chemistry - Juniper Publishers Abstract Simple, sensitive and accurate UV-spectroscopic methods ...

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Wolfram Syndrome with Primary Gonadal Insufficiency_Juniper publishers

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Global Journal of Reproductive Medicine    Juniper Publishers Authored by: Muhammed Kizilgul* Abstract A 24-year old male patient admitted to our clinic with the complaints of mouth dryness, polyuria, and polydipsia. He was diagnosed with tip 1 Diabetes Mellitus (DM) at the age of seven and intensive insulin therapy was instituted subsequently. Despite the stable blood glucose levels, the daily liquid intake of the patient was 10 liters, and the urine output was 9.5 liters. The patient also had complaints of loss of libido, impotence, erectile and ejaculatory dysfunction in the last 6 months. The insulin therapy was given as insulin aspart 4-unit t.i.d and insulin detemir 12 unit per day. In the physical examination, bilateral gynecomastia was observed. In the hormonal panel; FSH: 45 U/L (N:1.5-12.7), LH:28.4 U/L (N:1.7- 8.6), total testosterone: 3.83ng/ml (N:3-10ng/ml), free testosterone: 2.15pg/ml (N:12,00-30,00pg/ml). Bone mineral densitometry revealed low bone mass for
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